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<script language='javascript' src='http://www.beautyangleshop.com/Article/GetHits.asp?ArticleID=1046'></script></i></FONT> </td> <td width="42%" align="right"><FONT size=1><!-- AddThis Button BEGIN --> <a href="http://www.addthis.com/bookmark.php?v=250" onMouseOver="return addthis_open(this, '', '[URL]', '[TITLE]')" onMouseOut="addthis_close()" onClick="return addthis_sendto()"><img src="http://s7.addthis.com/static/btn/lg-share-en.gif" width="125" height="16" alt="Bookmark and Share" style="border:0"/></a><script type="text/javascript" src="http://s7.addthis.com/js/250/addthis_widget.js?pub=beautyangle"></script> <!-- AddThis Button END --> <a href='http://www.beautyangleshop.com/Article/Comment.asp?ArticleID=1046' target='_blank'>Comment</a> <a href='/User/User_Favorite.asp?Action=Add&ChannelID=1&InfoID=1046' target='_blank'>Favorite</a> <a href='http://www.beautyangleshop.com/Article/SendMail.asp?ArticleID=1046' target='_blank'>SendMail</a> <a href='http://www.beautyangleshop.com/Article/Print.asp?ArticleID=1046' target='_blank'>Print</a> <a href='javascript:window.close();'>Close</a> </FONT></td> </tr> </table> </td> </tr> <tr> <td class=bgc1 colSpan=3 height=1></td> </tr> <tr> <td valign="top" id=fontzoom height=300><P><STRONG><U>Pharmacology of flibanserin</U></STRONG></P> <P>Flibanserin has a preferential affinity for serotonin 5-HT (1A), dopamine D (4K), and serotonin 5-HT (2A) receptors. In vitro and in microiontophoresis, flibanserin behaves as a 5-HT (1A) agonist, a very weak partial agonist on dopamine D (4) receptors and 5-HT (2A) antagonist. In vivo flibanserin also binds to 5-HT (1A) and 5-HT (2A) receptors. However, under higher levels of brain 5-HT (less stress), May flibanserin occupy 5-HT (2A) receptors in the higher proportion of 5-HT (1A) receptors. The effects of flibanserin on adenylyl cyclase are different from those of buspirone and 8-OH-DPAT, two other purported 5-HT (1A) receptor agonists. Flibanserin reduces the rate of neuronal firing in cells of the dorsal raphe, hippocampus and cortex with the CA1 region is most sensitive in the brain. Flibanserin induced by reducing the frequency of firing in the cortex appears to be mediated by stimulation of postsynaptic 5-HT (1A) receptors, while reducing the number of active cells seems to be mediated by dopamine D (4) stimulation receptors. Flibanserin quickly desensitizes somatic 5-HT autoreceptors in the dorsal raphe and enhances tonic activation of postsynaptic 5-HT (1A) receptors in the CA3 region. Flibanserin preferentially reduces synthesis and extracellular levels of 5-HT in the cortex, where it increases levels of extracellular NE and DA. Flibanserin displays antidepressant-like activity in most animal models sensitive to antidepressants. Such activity, however, seems qualitatively different from that exercised by other antidepressants. Flibanserin appears to act by direct or indirect stimulation of 5-HT (1A), DA, and opioid receptors in these animal models. Flibanserin does not show systematic effects in animal models of anxiety and appears to exert potential antipsychotic effects. Flibanserin May induce some sedation but does not induce observable toxic effects at pharmacologically relevant doses.</P></p> <CENTER></CENTER></td> <td valign="top"></td> <td align="center" vAlign=top> <script language='javascript' src='/AD/200905/23.js'></script></td> </tr> <tr> <td colspan="4" align="right" valign="bottom"><div id="fb-root"></div><script src="http://connect.facebook.net/en_US/all.js#xfbml=1"></script><fb:like href="http://www.beautyangleshop.com/Article/ShowArticle.asp?ArticleID=1046" send="true" width="450" show_faces="true" action="like" font="tahoma"></fb:like> </td> </tr> <tr> <td align="center" colSpan=4 height=10> <script language='javascript' src='/AD/200810/2.js'></script></td> </tr> <tr> <td colSpan=3 height=6></td> </tr> <tr> <td style="font-family:Arial;" colSpan=3><em><li>Prev : <a class='LinkPrevArticle' href='http://www.beautyangleshop.com/Article/Health/Drug/200911/1045.html' title=' Title: Flibanserin clinical study side effects by:BeautyAngle 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<tr> <td bgcolor="#aaaaaa" height=28></td> <td bgcolor="#aaaaaa"><strong>Tags:</strong></td> <td bgcolor="#aaaaaa"></td> </tr> <tr> <td height=28></td> <td style="font-family:Arial;"><em><strong>flibanserin Pharmacology, Flibanserin side effects, female Viagra, women Viagra, Flibanserin Viagra, buy Flibanserin, buy Girosa</strong></em></td> <td></td> </tr> <tr> <td height=8></td><td></td><td></td> </tr> <tr> <td bgcolor="#aaaaaa" width=13 height=28></td> <td bgcolor="#aaaaaa"><FONT size=2><B>Related Articles</B></FONT></td> <td bgcolor="#aaaaaa" width=10></td> </tr> </table> <table cellSpacing=0 cellPadding=0 width="100%" border=0> <tr> <td width=1></td> <td vAlign=top> <table style="WORD-BREAK: break-all" cellSpacing=0 cellPadding=0 width="96%" align=center border=0> <tr> <td style="font-family:Arial;" vAlign=top height=70><FONT size=2><em><a class='LinkArticleCorrelative' href='http://www.beautyangleshop.com/Article/Health/Drug/200911/1047.html' title=' Title: Flibanserin Can not 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